Doxepin
別名: Sinequan, Adapin, Anten, Aponal, Deptran, Desidoxepin, Doneurin, Doxal, Doxepia, Gilex, Mareen, Quitaxon, Triadapin, Xepin, Zonalon, Sinepin
- **Patience is Key:** Several weeks (often 3-4 weeks) may be required before noticeable behavioral or dermatological efficacy is seen. Continue dosing exactly as prescribed. - **Safety First:** All tricyclic antidepressants should be dispensed in child-resistant packaging and kept well away from children and pets. Overdoses can be fatal. - **Do Not Stop Abruptly:** Consult your veterinarian before discontinuing the medication to avoid potential withdrawal effects. - **Monitor for Side Effects:** Contact your veterinarian if your pet exhibits extreme lethargy, unexpected hyperactivity, vomiting, or signs of a rapid/irregular heartbeat.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Treatment of psychogenic dermatoses
- Excessive grooming
- Treatment of behavior problems (e.g., overgrooming, intercat aggression)
- Treatment of anxiety, pruritus caused feather plucking in psittacines
- Treatment of anxiety, pruritus caused feather plucking in psittacines
- Treatment of psychogenic dermatoses
- Treatment of psychogenic dermatoses
- Antihistaminic effects in treatment of atopy
- Antihistaminic effects in treatment of atopy
- Antihistaminic effects in treatment of atopy
- Antihistaminic effects in treatment of atopy
- Treatment of behavior problems (OCD)
給藥方式
可能的副作用
- Hyperexcitability (paradoxical)
- Gastrointestinal distress
- Lethargy and sedation
- Ventricular arrhythmias (particularly in overdose)
- Anticholinergic effects (dry mouth, urinary retention, constipation)
- Altered blood glucose levels
- Sedation
- Lethargy
- Dry mouth (xerostomia)
- Tachycardia
- Urinary retention
- Constipation
注意事項與禁忌
- Prior sensitivity to doxepin or other tricyclic antidepressants
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) such as selegiline or amitraz (within 14 days)
- Urinary retention
- Glaucoma
- Severe cardiac disease
- History of seizures
- Concurrent use with MAOIs
- **Pregnancy & Nursing:** Safety during pregnancy has not been established (FDA Category C). Doxepin and its active metabolite distribute into milk; use with caution in nursing patients as sedation and respiratory depression have been reported in human infants. **Cardiac Effects:** Tricyclics can widen QRS complexes, prolong PR intervals, and invert or flatten T-waves on ECG. Use with caution in patients with pre-existing cardiac disease. **Laboratory Alterations:** May alter (increase or decrease) blood glucose levels.
藥物相互作用
- Anticholinergic Agents: Additive anticholinergic effects; use cautiously.
- Cimetidine: May inhibit tricyclic antidepressant metabolism and increase the risk of toxicity.
- CNS Depressants: Additive CNS depression; use cautiously.
- Meperidine, Pentazocine, Dextromethorphan: Increased risk for serotonin syndrome.
- Monoamine Oxidase Inhibitors (MAOIs, e.g., amitraz, selegiline): Concomitant use (within 14 days) is generally contraindicated due to high risk of serotonin syndrome.
- Quinidine: Increased risk for QTc interval prolongation and tricyclic adverse effects.
- SSRIs (e.g., fluoxetine, paroxetine, sertraline): Increased risk for serotonin syndrome.
- Sympathomimetic Agents: May increase the risk of cardiac effects (arrhythmias, hypertension, hyperpyrexia).
- Monoamine Oxidase Inhibitors (MAOIs): Risk of fatal serotonin syndrome
- Selective Serotonin Reuptake Inhibitors (SSRIs): Increased risk of serotonin syndrome
常見問題
Doxepin用於寵物有甚麼用途？
- **Patience is Key:** Several weeks (often 3-4 weeks) may be required before noticeable behavioral or dermatological efficacy is seen. Continue dosing exactly as prescribed. - **Safety First:** All tricyclic antidepressants should be dispensed in child-resistant packaging and kept well away from children and pets. Overdoses can be fatal. - **Do Not Stop Abruptly:** Consult your veterinarian before discontinuing the medication to avoid potential withdrawal effects. - **Monitor for Side Effects:** Contact your veterinarian if your pet exhibits extreme lethargy, unexpected hyperactivity, vomiting, or signs of a rapid/irregular heartbeat.
Doxepin對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。