Diethylstilbestrol
別名: Apstil, Boestrol, Destilbenol, Distilbene
Diethylstilbestrol (DES) is a hormone used primarily to treat urinary incontinence (leaking urine) in spayed female dogs. * **Strict Dosing:** It is critical to give this medication *exactly* as prescribed. Giving more than the recommended dose can lead to fatal bone marrow disease. * **Watch for Bleeding/Infection:** Contact your veterinarian immediately if you notice pale gums, unexplained bruising, lethargy, weakness, or fever. * **Watch for Pyometra Signs:** If your pet is an unspayed female, watch for excessive water consumption, frequent urination, or abnormal discharge from the vulva, which could indicate a severe uterine infection. * **Other Signs to Report:** Diarrhea, vomiting, or signs of being in "heat" (swollen vulva, bleeding). * **Handling:** Wash your hands after handling the medication, and keep it strictly out of reach of children and other pets.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Estrogen-responsive incontinence (females)
- Primary sphincter mechanism incompetence (Option A)
- Primary sphincter mechanism incompetence (Option B - females)
- Primary sphincter mechanism incompetence (Option C)
- Estrus induction
- Benign prostatic hypertrophy
給藥方式
可能的副作用
- Bone marrow suppression (thrombocytopenia, leukopenia, fatal aplastic anemia)
- Cystic endometrial hyperplasia
- Pyometra (in intact females)
- Mammary neoplasia
- Feminization (in males)
- Signs of estrus (in females)
- Pancreatic, hepatic, and cardiac lesions (reported in cats)
- Malignant ovarian adenocarcinomas (experimental)
注意事項與禁忌
- Food-producing animals (FDA prohibited)
- Pregnancy (teratogenic; causes fetal genitourinary malformations)
- Patients with preexisting anemias or leukopenias
- Females with estrogen-sensitive neoplasms
- **WARNING:** DES is strictly prohibited by the FDA for use in food animals due to carcinogenic potential. * **Bone Marrow Toxicity:** Estrogens are toxic to the bone marrow in dogs and cats. Use with extreme caution in patients with preexisting hematologic abnormalities. Toxicity is dose-dependent and more common in older animals. * **Pyometra Risk:** Can induce cystic endometrial hyperplasia and open-cervix pyometra in intact females 1-6 weeks after initiating therapy. * **Carcinogenicity:** May induce mammary neoplasias and has been linked to malignant ovarian adenocarcinomas in experimental settings.
藥物相互作用
- Azole Antifungals (itraconazole, ketoconazole, etc.): May increase estrogen levels
- Cimetidine: May decrease metabolism of estrogens
- Corticosteroids: Enhanced glucocorticoid effects may result; estrogens may alter protein binding or decrease metabolism of corticosteroids
- Erythromycin, Clarithromycin: May decrease the metabolism of estrogens
- Warfarin: Oral anticoagulant activity may be decreased; increases in anticoagulant dosage may be necessary
- Phenobarbital: May decrease estrogen concentrations
- Phenytoin: May decrease estrogen concentrations
- Rifampin: May induce hepatic microsomal enzymes and decrease estrogen levels
常見問題
Diethylstilbestrol用於寵物有甚麼用途？
Diethylstilbestrol (DES) is a hormone used primarily to treat urinary incontinence (leaking urine) in spayed female dogs. * **Strict Dosing:** It is critical to give this medication *exactly* as prescribed. Giving more than the recommended dose can lead to fatal bone marrow disease. * **Watch for Bleeding/Infection:** Contact your veterinarian immediately if you notice pale gums, unexplained bruising, lethargy, weakness, or fever. * **Watch for Pyometra Signs:** If your pet is an unspayed female, watch for excessive water consumption, frequent urination, or abnormal discharge from the vulva, which could indicate a severe uterine infection. * **Other Signs to Report:** Diarrhea, vomiting, or signs of being in "heat" (swollen vulva, bleeding). * **Handling:** Wash your hands after handling the medication, and keep it strictly out of reach of children and other pets.
Diethylstilbestrol對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。