Dichlorphenamide
別名: Daranide, Antidrasi, Fenamide, Glaucol, Glauconide, Glaumid, Oralcon, Oratrol, Tensodilen
* **Administration**: Give this medication exactly as prescribed. If your pet experiences stomach upset (vomiting or loss of appetite), try giving the dose with a small meal or treat. * **What to Watch For**: Contact your veterinarian immediately if you notice: * Unusual bleeding or bruising (could indicate bone marrow suppression). * Muscle tremors, weakness, or severe lethargy (signs of low potassium). * Skin rashes or excessive panting. * **Follow-up**: Regular check-ups are crucial to monitor your pet's eye pressure (glaucoma) and blood work (electrolytes and blood cell counts). > **Note**: This medication is often custom-made (compounded) since commercial tablets are rarely available. Ensure you get refills well in advance.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive treatment of glaucoma
- Adjunctive treatment of glaucoma
- Adjunctive treatment of glaucoma
- Adjunctive treatment of glaucoma
- Adjunctive treatment of glaucoma
給藥方式
可能的副作用
- Panting
- GI disturbances (inappetence, vomiting, diarrhea)
- CNS effects (sedation, depression, excitement)
- Hematologic effects (bone marrow depression)
- Renal effects (crystalluria, dysuria, renal colic, polyuria)
- Metabolic acidosis
- Hypokalemia
- Hyperglycemia
- Hyponatremia
- Hyperuricemia
- Hepatic insufficiency
- Dermatologic effects (rash)
- Hypersensitivity reactions
注意事項與禁忌
- Significant hepatic disease (may precipitate hepatic coma)
- Renal or adrenocortical insufficiency
- Hyponatremia
- Hypokalemia
- Hyperchloremic acidosis
- Electrolyte imbalance
- Severe pulmonary obstruction (unable to increase alveolar ventilation)
- Hypersensitivity to carbonic anhydrase inhibitors
- Chronic, noncongestive, angle-closure glaucoma (long-term use)
- > **Warning**: Long-term use is contraindicated in patients with chronic, noncongestive, angle-closure glaucoma as it may mask the condition by lowering IOP while angle closure progresses. * Use with extreme caution in patients with pre-existing electrolyte imbalances (especially hypokalemia or hyponatremia). * May precipitate hepatic coma in patients with severe liver disease. * Avoid in patients with severe pulmonary obstruction who cannot increase alveolar ventilation to compensate for metabolic acidosis. * **Pregnancy Category C**: Teratogenic effects observed in animal studies; use only if benefits outweigh risks. * **Laboratory Interference**: May cause false-positive results for urine protein using certain test methods (e.g., bromphenol blue, sulfosalicylic acid) due to urine alkalinization. May also decrease iodine uptake by the thyroid gland.
藥物相互作用
- Antidepressants, Tricyclic: Alkaline urine caused by dichlorphenamide may decrease excretion of tricyclic antidepressants.
- Aspirin (or other salicylates): Increased risk of dichlorphenamide accumulation and toxicity; increased risk for metabolic acidosis; dichlorphenamide increases salicylate excretion.
- Digoxin: Dichlorphenamide may cause hypokalemia, leading to an increased risk for digoxin toxicity.
- Insulin: Rarely, carbonic anhydrase inhibitors interfere with the hypoglycemic effects of insulin.
- Methenamine compounds: Dichlorphenamide may negate the effects of methenamine in the urine due to alkalinization.
- Potassium-depleting drugs (corticosteroids, amphotericin B, corticotropin, diuretics): Concomitant use may exacerbate potassium depletion.
- Phenobarbital: Increased urinary excretion, which may reduce phenobarbital levels.
- Primidone: Decreased primidone concentrations.
- Quinidine: Alkaline urine caused by dichlorphenamide may decrease quinidine excretion.
常見問題
Dichlorphenamide用於寵物有甚麼用途？
* **Administration**: Give this medication exactly as prescribed. If your pet experiences stomach upset (vomiting or loss of appetite), try giving the dose with a small meal or treat. * **What to Watch For**: Contact your veterinarian immediately if you notice: * Unusual bleeding or bruising (could indicate bone marrow suppression). * Muscle tremors, weakness, or severe lethargy (signs of low potassium). * Skin rashes or excessive panting. * **Follow-up**: Regular check-ups are crucial to monitor your pet's eye pressure (glaucoma) and blood work (electrolytes and blood cell counts). > **Note**: This medication is often custom-made (compounded) since commercial tablets are rarely available. Ensure you get refills well in advance.
Dichlorphenamide對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。