Dexrazoxane
別名: Zinecard, Cardioxane, Eucardion, Totect
* **Purpose**: Your pet is receiving this medication to protect their heart from the side effects of certain chemotherapy drugs (like doxorubicin) or to treat severe tissue damage if chemotherapy accidentally leaks outside the vein. * **Cost & Expectations**: This is a highly specialized and expensive medication. While it significantly reduces the risk of heart damage or tissue injury, it may not be fully effective in all cases. * **Side Effects**: It may lower your pet's white blood cell count, making them more susceptible to infections. We will monitor their bloodwork closely. * **Safety**: Because this drug is given alongside chemotherapy, follow your veterinarian's instructions regarding handling your pet's waste safely at home.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Treatment of anthracycline (doxorubicin, epirubicin, etc.) extravasation
- Treatment of anthracycline extravasation
- Prevention of doxorubicin-induced cardiomyopathy
- Prevention of doxorubicin-induced cardiomyopathy
給藥方式
可能的副作用
- Additive myelosuppression
- Potential reduction in efficacy of anthracycline antitumor agents
- Testicular atrophy (observed in dogs)
- Myelosuppression (documented in humans)
- Decreased clinical efficacy of anthracycline antineoplastic agents
注意事項與禁忌
- Should not be used unless an anthracycline antineoplastic agent is being used
- Unknown based on monograph, but generally avoid in patients not receiving anthracyclines
- > **Important**: Dexrazoxane should not be used unless an anthracycline antineoplastic agent is being administered. * **Species Limitations**: Efficacy and safety for use in cats is not known. * **Reproductive Safety**: Causes testicular atrophy in dogs when administered at usual doses for 13 weeks. Teratogenic in rats and rabbits at doses lower than human doses (FDA Category C). Nursing mothers should discontinue nursing. * **Handling Warnings**: Wear gloves when handling. Use normal procedures for handling and disposal of anti-cancer medications. If unreconstituted powder contacts skin or mucous membranes, wash off thoroughly with soap and water.
藥物相互作用
- Myelosuppressive agents: Additive myelosuppression may occur when used concurrently.
- Anthracycline antineoplastic agents: May decrease the clinical efficacy of the chemotherapy
常見問題
Dexrazoxane用於寵物有甚麼用途？
* **Purpose**: Your pet is receiving this medication to protect their heart from the side effects of certain chemotherapy drugs (like doxorubicin) or to treat severe tissue damage if chemotherapy accidentally leaks outside the vein. * **Cost & Expectations**: This is a highly specialized and expensive medication. While it significantly reduces the risk of heart damage or tissue injury, it may not be fully effective in all cases. * **Side Effects**: It may lower your pet's white blood cell count, making them more susceptible to infections. We will monitor their bloodwork closely. * **Safety**: Because this drug is given alongside chemotherapy, follow your veterinarian's instructions regarding handling your pet's waste safely at home.
Dexrazoxane對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。