Danazol
別名: Danocrine
* **Patience is key**: It may take **2 to 3 months** to see a positive response with this drug. Do not stop the medication abruptly unless instructed by your veterinarian. * **Monitor for liver issues**: Watch for signs of liver toxicity such as yellowing of the eyes, skin, or gums (jaundice), loss of appetite, or vomiting. * **Watch for bleeding**: Since this is often used for blood disorders, monitor for dark, tarry stools, unusual bruising, or bleeding gums. * **Handling precautions**: Pregnant women should avoid handling this medication due to the risk of birth defects.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive treatment of immune-mediated hemolytic anemia
- Adjunctive treatment of immune-mediated hemolytic anemia (non-regenerative forms)
- Adjunctive treatment of immune-mediated hemolytic anemia or thrombocytopenia
- Adjunctive treatment of immune-mediated hemolytic anemia or thrombocytopenia
給藥方式
可能的副作用
- Hepatotoxicity (rare but significant in dogs)
- Virilization in females
- Weight gain
- Lethargy
- Edema
- Testicular atrophy
- Hirsutism
- Alopecia
- Vaginitis (reported in humans)
注意事項與禁忌
- Pregnancy (Teratogenic - FDA Category X)
- Nursing/breastfeeding
- Severe cardiac function impairment
- Severe renal function impairment
- Severe hepatic function impairment
- Undiagnosed abnormal vaginal bleeding
- > **Warning**: Danazol is highly teratogenic (FDA Category X) and must not be handled by pregnant women or used in pregnant animals. * Use with extreme caution in patients with pre-existing **hepatic, renal, or cardiac dysfunction**. * **Laboratory Alterations**: May alter thyroid panel results (decreased total T4, increased T3 uptake) without causing true hypothyroidism (free T4 and TSH remain normal). * ALT (SGPT) and AST (SGOT) may increase early in therapy but typically decrease towards baseline later in therapy or after discontinuation.
藥物相互作用
- Cyclosporine: May significantly increase cyclosporine levels
- Insulin: By affecting carbohydrate metabolism, danazol may affect insulin requirements (doses may need to be increased) in diabetic patients
- Warfarin: Concomitant use may enhance the anticoagulant effect as danazol may decrease the synthesis of procoagulant factors in the liver
常見問題
Danazol用於寵物有甚麼用途？
* **Patience is key**: It may take **2 to 3 months** to see a positive response with this drug. Do not stop the medication abruptly unless instructed by your veterinarian. * **Monitor for liver issues**: Watch for signs of liver toxicity such as yellowing of the eyes, skin, or gums (jaundice), loss of appetite, or vomiting. * **Watch for bleeding**: Since this is often used for blood disorders, monitor for dark, tarry stools, unusual bruising, or bleeding gums. * **Handling precautions**: Pregnant women should avoid handling this medication due to the risk of birth defects.
Danazol對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。