Carvedilol
別名: Coreg, Coreg CR, Eucardic
### Important Information for Pet Owners * **Strict Dosing:** Give this medication *exactly* as your veterinarian prescribes. **Do not stop the medication abruptly** without the approval and guidance of your veterinarian, as this can cause a dangerous rebound effect on the heart. * **Watch for Worsening Signs:** Contact your veterinarian immediately if your pet's condition worsens while receiving this medication (e.g., increased coughing, difficulty breathing). * **Monitor for Side Effects:** Call your vet if your pet shows signs of reduced appetite, severe fatigue or listlessness, dizziness, or unsteadiness (which may indicate low blood pressure). * **Administration:** This medication is best given with food to help with absorption and reduce the risk of sudden blood pressure drops.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Heart failure (adjunctive therapy)
- Early/mild heart failure or later stages of CHF
- Heart failure (target plasma concentration)
- Dilated cardiomyopathy
- Chronic heart failure / Dilated Cardiomyopathy (DCM)
- ACVIM stage B2 degenerative mitral valve disease
給藥方式
可能的副作用
- Inappetence
- Lassitude (lethargy/fatigue)
- Hypotension
- Decompensation of heart failure (if titrated too rapidly)
- Bronchospasm (reported in humans)
- Mild hepatocellular injury (rare)
注意事項與禁忌
- Class IV decompensated heart failure
- Bronchial asthma
- 2nd or 3rd degree AV block
- Sick sinus syndrome (unless artificially paced)
- Severe bradycardia
- Cardiogenic shock
- Hypersensitivity to the drug
- > **Black Box Warning Equivalent:** Too rapid beta blockade can cause decompensation in patients with heart failure; cautious dosage titration is mandatory. * **Hepatic Insufficiency:** Because the drug is extensively metabolized in the liver, patients with hepatic insufficiency should receive the drug with caution. * **Pregnancy/Nursing:** FDA Category C. Increased post-implantation loss seen in animal studies. Unknown if it enters canine milk, but does enter rat milk. Use with caution in nursing patients.
藥物相互作用
- Beta-Blockers (other): Use with carvedilol may cause additive effects
- Calcium Channel Blockers (e.g., diltiazem, verapamil): May rarely cause hemodynamic compromise
- Cimetidine: May decrease metabolism and increase AUC of carvedilol
- Clonidine: Carvedilol may potentiate the cardiovascular effects of clonidine
- Cyclosporine: Carvedilol may increase cyclosporine levels
- Digoxin: Can increase digoxin plasma concentrations by approximately 15%
- Fluoxetine, Paroxetine, Quinidine: May increase R(+)carvedilol concentrations and increase alpha-1 blocking effects (vasodilation)
- Insulin / Oral Antidiabetic Agents: Carvedilol may enhance the blood glucose lowering effects of insulin or other antidiabetic agents
- Rifampin: Can decrease carvedilol plasma concentrations by as much as 70%
- Reserpine: Can cause increased bradycardia and hypotension in patients taking carvedilol
- Anaesthetic agents: Enhanced hypotensive effect and myocardial depression
常見問題
Carvedilol用於寵物有甚麼用途？
### Important Information for Pet Owners * **Strict Dosing:** Give this medication *exactly* as your veterinarian prescribes. **Do not stop the medication abruptly** without the approval and guidance of your veterinarian, as this can cause a dangerous rebound effect on the heart. * **Watch for Worsening Signs:** Contact your veterinarian immediately if your pet's condition worsens while receiving this medication (e.g., increased coughing, difficulty breathing). * **Monitor for Side Effects:** Call your vet if your pet shows signs of reduced appetite, severe fatigue or listlessness, dizziness, or unsteadiness (which may indicate low blood pressure). * **Administration:** This medication is best given with food to help with absorption and reduce the risk of sudden blood pressure drops.
Carvedilol對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。