Atenolol

What it is used for

• Treatment of hypertension or cardiac conditions (e.g., hypertrophic cardiomyopathy)
• Treatment of hypertension or cardiac conditions
• Treatment of choice for hyperthyroid, hypertensive cats
• Hypertrophic cardiomyopathy
• Hypertrophic cardiomyopathy
• Cardiac arrhythmias, obstructive heart disease, hypertension, myocardial infarction, etc.
• Moderate to severe sub-valvular aortic stenosis (SAS)
• To attempt to decrease syncopal episodes associated with pulmonic stenosis
• Hypertension

How it is given

Possible side effects

• Lethargy
• Hypotension
• Diarrhea
• Bradycardia
• Inappetence
• Depression
• Impaired AV conduction
• Worsening of heart failure
• Hypoglycemia
• Syncope
• Bronchoconstriction (rare at normal doses)

Cautions & contraindications

• Overt heart failure
• Hypersensitivity to beta-blockers
• Greater than first-degree heart block
• Sinus bradycardia
• Cats with hypertrophic cardiomyopathy with accompanying pulmonary edema
• > **Withdrawal Warning:** Exacerbation of symptoms has been reported following abrupt cessation of beta-blockers. It is highly recommended to withdraw therapy gradually in patients who have been receiving the drug chronically. * **Renal Impairment:** Use cautiously in patients with significant renal insufficiency as the drug is primarily excreted unchanged in the urine. * **Endocrine:** Can mask clinical signs associated with hypoglycemia and thyrotoxicosis. Use cautiously in labile diabetic patients as it can cause hypo- or hyperglycemia. * **Cardiac:** Use cautiously in patients with sinus node dysfunction. Non-specific beta-blockers are generally contraindicated in patients with CHF unless secondary to a tachyarrhythmia responsive to beta-blocker therapy.

Drug interactions

• Anesthetics (myocardial depressants): Additive myocardial depression may occur with concurrent use.
• Calcium-Channel Blockers (e.g., diltiazem, verapamil, amlodipine): Concurrent use should be done with caution due to additive negative inotropic effects, particularly in patients with preexisting cardiomyopathy or CHF.
• Clonidine: Atenolol may exacerbate rebound hypertension after stopping clonidine therapy.
• Furosemide, Hydralazine, or other hypotensive drugs: May increase the hypotensive effects of atenolol.
• Phenothiazines: Concurrent use may exhibit enhanced hypotensive effects.
• Reserpine: Potential for additive effects including hypotension and bradycardia.
• Sympathomimetics (e.g., metaproterenol, terbutaline, epinephrine, phenylpropanolamine): May have their actions blocked by atenolol, and they may in turn reduce the efficacy of atenolol.

Întrebări frecvente